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Before launch, this is what normal looks like.
4 civilians. 71 biomarkers. All within normal range.
Act II — Ascent
September 15-18, 2021. SpaceX Crew Dragon Resilience. 3 days in low Earth orbit at 590 km — higher than any human has orbited since the Hubble servicing missions.
Act III — The Storm
Pre-flight (L-92)
Post-flight (R+1)
Composite Inflammation Score — All Crew
Cross-omics confirmation — the same signal from 3 angles
Cytokine Z-Scores at R+1
IL-6
TNF-α
MCP-1
CBC Shifts
WBC
Neutrophils
Lymphocytes
Metabolic Flags
Glucose
ALT
Calcium
Every biological layer tells the same story: systemic inflammatory activation at R+1.
Act IV — The Divergence
Post-flight recovery trajectories
IL-6
TNF-Α
IL-10
MCP-1
VEGF
IFNΓ
Each crew member recovers on their own timeline.
Act V — The Fingerprint
Domain Severity at R+1
Biosovereignty starts with legibility. This is your body. This is what spaceflight did to it. This is your recovery.
Act VI — The Tool
| Marker | L-92 | L-44 | L-3 | R+1 | R+45 | R+82 | R+194 |
|---|---|---|---|---|---|---|---|
| il-6 | -0.5 | -0.7 | +1.1 | +1.6 | -1.1 | -1.5 | +0.3 |
| il-8 | +1.0 | -1.0 | 0.0 | +0.1 | -0.8 | -0.9 | -0.4 |
| il-10 | +0.5 | -1.1 | +0.7 | +2.8 | -0.8 | +1.6 | +0.8 |
| tnf-α | · | · | · | · | · | · | · |
| mcp-1 | +0.5 | -1.1 | +0.7 | +1.9 | -1.1 | -0.6 | -0.4 |
| vegf | · | · | · | · | · | · | · |
| il-1ra | +0.2 | -1.1 | +0.9 | +0.5 | -1.0 | -0.0 | -1.5 |
| ifnγ | -0.5 | +1.1 | -0.6 | -0.8 | -1.3 | +23.6 | -0.9 |
| il-4 | +0.2 | -1.1 | +0.9 | +1.0 | -0.4 | -1.3 | -0.0 |
| il-13 | +0.5 | -1.1 | +0.7 | +0.9 | -0.9 | +57.7 | +0.6 |
| il-15 | +0.3 | -1.1 | +0.8 | +2.3 | -0.4 | +2.5 | +1.0 |
| il-27 | +0.7 | -1.1 | +0.5 | +3.3 | -0.5 | +1.6 | -0.0 |
| ip-10 | +0.8 | -1.1 | +0.3 | +2.8 | -1.2 | +7.2 | -0.6 |
| fractalkine | +0.5 | -1.1 | +0.6 | +1.1 | -0.3 | +17.9 | +0.3 |
| g-csf | -0.3 | +1.1 | -0.8 | +1.4 | -3.5 | +0.4 | -2.0 |
| gm-csf | -0.0 | +1.0 | -1.0 | +0.6 | -6.4 | +69.5 | +1.6 |
| eotaxin | +0.8 | -1.1 | +0.4 | +1.9 | +0.1 | +10.3 | +0.5 |
| rantes | +0.7 | -1.1 | +0.5 | -1.4 | -1.1 | -1.1 | -0.8 |
| tpo | -0.5 | -0.7 | +1.1 | +1.9 | -3.0 | -1.4 | -1.9 |
| il-18 | -0.7 | +1.1 | -0.5 | -0.6 | -2.1 | -6.1 | -1.1 |
Methodology
n=4. No control group. Z-scores computed per crew member against their own pre-flight baseline (L-92, L-44, L-3). Domain scores = mean |z-score| across constituent biomarkers. Recovery Readiness Score = % of markers within 1 SD of pre-flight mean. All cytokine concentrations in pg/mL via Eve Technologies multiplex panel. CBC from Quest Diagnostics.